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姚建銓院士團隊在國際TOP期刊Nanoscale上發表最新研究成果

發布時間:2019-12-09  來源:   查看:

近日,由我校特聘院士姚建銓、光電工程學院梁蘭菊教授共同指導,光電工程學院閆昕博士和聯合培養張璋博士、楊茂生博士在太赫茲生物傳感器方面的研究工作取得最新進展,相關成果發表在國際期刊《Nanoscale》(SCI一區,TOP期刊,影響因子6.97)上,閆昕博士與張璋博士為共同第一作者,楊茂生博士為通訊作者。

團隊提出并制備了一種基于高階法諾共振超材料的多模式諧振生物傳感器。該傳感器通過超材料的四偶極子,八偶極子,十六偶極子法諾共振的頻移以及頻移的集成化圖形探測肺癌細胞的濃度。實驗研究得到,隨著細胞濃度的增加,法諾共振的頻移Δf依次經歷增加頻移(IFSS),減少頻移(DFSS)和重新增加的頻移(RIFSS)。通過引入新的介電常數εf,修正了微擾理論以解釋Δf中的異常現象。研究結論為太赫茲生物傳感器的制備提供了一種新的途徑。

上述研究成果得到了國家重點研發計劃項目(2017YFA0700202)、國家自然科學基金(61701434, 61735010)、山東省自然科學基金(ZR2017MF005,ZR2018LF001 )、棗莊市自主創新及成果轉化項目基金(2016GH19)、山東省院士專家工作站、山東省光電信息處理與顯示重點實驗室,教育部重點實驗室(天津大學)的資助。

截至目前,姚建銓院士指導棗莊學院太赫茲科研團隊2019年在太赫茲相關領域發表科研論文20篇,其中SCI論文12篇,中科院JCR一區文章3篇,二區文章3篇,ESI高被引論文1篇。


Figure. 1 (a) Schematic diagram of the unit cells for the high order FRMMs, the corresponding structural parameters are: p = 50 μm, w = 200nm, l = 20 μm, d = 40 μm, g = 8 μm, h =10μm. (b) Simulated transmittance spectra for the x-polarized (black curve) and the y-polarized (red curve) incidence wave. (c) Schematic diagram for the periodic structure. (d) Experimental transmittance spectra for the x-polarized (black dotted curve) and they-polarized (red dotted curve) incidence wave.

Figure. 2 Schematic representation of culturing cells method on higher order FRMMs-based biosensors with A549 cells binding to the metal surface and its equivalent dielectric environment transition mechanism.

Figure. 3 Micrographs of the higher order FRMMs-based biosensor with cell A549 at different concentration changing from 1×104 cel3ls/ml to 5×105cell/ml.

Figure. 4 The measured x-polarized transmittance spectrum of the proposed higher order FRMMs-based biosensors under different cell concentrations (1×104cells/ml, 3×104cells/ml, 5×104cells/ml, 1×105cells/ml, 3×105cells/ml, 5×105cells/ml). (h), (j), (i) The measured x-polarized frequency shift Δf of Qx, Ox and Hx extracted from (a),(b), (c), (d), (e), (f).

Figure. 5 The measured y-polarized transmittance spectrum of the designed higher order higher order FRMMs-based biosensors under different cell concentrations (1×104 cells/ml, 3×104 cells/ml, 5×104 cells/ml, 1×105 cells/ml, 3×105 cells/ml, 5×105 cells/ml) (h), (i) The measured x-polarized frequency shift Δf of Qy and Oy extracted from (a),(b), (c), (d), (e), (f).

Figure. 6 the shapes and distributions of graphics integrated with the Δf for each resonant mode under different cell concentration.


文章鏈接網址:https://pubs.rsc.org/en/results/journals?Category=journal&AllText=%2010.1039%2FC9NR07777D%20&IncludeReference=false&SelectJournal=True&ArtRefJournalName=Nanoscale%3B&DateRange=false&SelectDate=false&PriceCode=False&OpenAccess=false&JournalName=Nanoscale

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